Regenerative Energie
5-Fluorouracil (5-FU) is a popular anticancer drug. In the year 2002, 5-FU was administered over 2 million patients worldwide, and its overall production was estimated to 5000 kg per year. Approximately 2-35% of the administered 5-FU is excreted via urine within 24 h [2,3] which in fact enters into the hospital effluents and consequently contaminates aquatic environment. Antineoplastic drugs such as cyclophosphamide, infosfamide, 5-FU, doxorubicin, epirubicin and daunorubicin were identified in hospital waste water of oncogenic department at countable concentrations; where 5-FU was detected at higher concentration.
The growing use of 5-fluorouracil drugs in cancer therapy has appeared as important issue for discussion of its environmental effects. 5-fluorouracil interferes with growth of green microalgae, Scenedesmus vacuolatus. It magnifies in microalgae and consequently demonstrated the bioaccumulation factor of 18.4×103. However, it does not only accumulate in the microalgae cell but also integrates into the genome. About 0.49 and 0.68 percent of initial applied radio-labelled 5-fluorouracil were detected in the DNA and RNA of microalgae respectively. Furthermore, the labelled microalgae genome was transferred into Tetrahymena pyriformis when added them in the culture. The second organism fed the labelled genome and retained some labelled 5-fluorouracil away from excretion of microalgae genome through food vacuoles. This bio-transfer of labelled 5-fluorouracil via genomic material was evaluated with the exhibition of radioactivity in Tetrahymena cell pellets. However, radioactivity did not detected in the genome of predator organism.
| Copyright: | © Aristotle University of Thessaloniki |
| Quelle: | 2nd International Conference 2009 (Juni 2009) |
| Seiten: | 6 |
| Preis: | € 5,00 |
| Autor: | Asad Ud-Daula Linda Pfister Karl-Werner Schramm |
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Rechtliche und praktische Unsicherheiten bei der Durchführung des europäischen Klimaanpassungsrechts durch das Bundes- Klimaanpassungsgesetz (KAnG)
© Lexxion Verlagsgesellschaft mbH (6/2025)
In the context of the European Climate Law (EU) 2021/1119), the Governance Regulation (EU) 2018/1999 and the Nature Restoration Regulation (EU) 2024/1991, the KAnG came into force on July 1, 2024.
Transformatives Klimarecht: Raum, Zeit, Gesellschaft
© Lexxion Verlagsgesellschaft mbH (6/2025)
This article contends that climate law should be conceived as inherently transformative in a double sense. The law not only guides the necessary transformation of economy and society, but is itself undergoing transformation.
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© Springer Vieweg | Springer Fachmedien Wiesbaden GmbH (5/2025)
Die Landestalsperrenverwaltung des Freistaates Sachsen (LTV) betreibt aktuell insgesamt 87 Stauanlagen, darunter 25 Trinkwassertalsperren. Der Stauanlagenbestand ist historisch gewachsen und wurde für unterschiedliche Zwecke errichtet.